The chemical Effexor's structure can not be attributed to any prominent antidepressant class (tricyclic, tetracyclic and etc). It has two enantiomeric active racemic forms.
Effexor's antidepressant effect is related to increased activity of neurotransmitter in the CNS. Effexor and its main metabolite O-desmethylvenlafaxine are powerful inhibitors of serotonin's and norepinephrine's reuptake and weakly inhibits reuptake of dopamine neurons. Effexor and O-desmethylvenlafaxine influence equally effective on neurotransmitters' reuptake. Effexor and desvenlafaxine reduce beta adrenergic response.
Indications for use:
depression (with or without anxiety symptoms), outpatient (inpatient) treatment;
recurrence prevention after a first depression episode or new relapses prevention;
generalized anxiety disorder;
Dosage and administration :
Is taken perorally. Effexor's initial dose of 75 mg is divided on 2 receptions (37.5 mg 2 times/day ). If several week treatment didn't show significant improvement, the dosage can be enlarged up to 150 mg (75 mg of Effexor 2 times/day). In severe depression cases or other conditions requiring inpatient treatment can be at once used 150 mg in 2 receptions (75 mg 2 times/day). Thereafter, the daily dosage can be increased on 75 mg every 2-3 days until the acceptable therapeutic effect appears. The maximum dose - 375 mg/day.